J.Jpn. Surg. Soc.. 104(6): 439-442, 2003
Feature topic
PATHOLOGY OF INTRADUCTAL PAPILLARY-MUCINOUS TUMOR OF THE PANCREAS
|
Department of Pathology (I), Juntendo University School of Medicine, Tokyo, Japan Bunsei Nobukawa, Koichi Suda, Shigetaka Yamasaki, Masaru Takase, Yuki Fukumura, Saori Shiono |
The histology of IPMT is various, including hyperplasia to invasive carcinoma IPMTs are thought to occur multicentrically through the hyperplasia-adenoma-carcinoma sequence. IPMTs are characterized by genetic heterogeneity associated with histologic heterogeneity that may be due to slow growth and favorable prognosis. However, some IPMTs progress to invasive pancreatic cancer through malignant transformation with aggressive clonal progression. Thus some conventional pancreatic cancers may be derived from IPMTs. Although IPMTs and conventional pancreatic cancer initially occur in the ductal epithelium, they are thought to be totally different entities in terms of large or peripheral pancreatic duct origin, developmental style, genetic alterations, and prognosis. In future, differences and/or similarities will be discussed on the basis of molecular analyses of the carcinogensis of both tumors.
To read the PDF file you will need Adobe Reader installed on your computer.