J.Jpn. Surg. Soc.. 93(3): 274-287, 1992

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Original article

ASSESSMENT FOR PROTECTIVE EFFECTS OF CoQ₁₀, PGE₁ and TXA₂ RECEPTOR ANTAGONIST (ONO-3708) ON WARM ISCHEMIC LIVER

Metabolic disturbances in the canine liver during warm ischemia by Pringle's method for 60 minutes and the role of Coenzyme Q₁₀ (CoQ₁₀), Prostaglandin E₁ (PGE₁) and ON0-3708, TXA₂ receptor antagonist, were studied. Mongrel dogs were devided into five groups; control group, group of liver ischemia without drugs, groups of liver ischemia with CoQ₁₀, PGE₁ and ON0-3708 pretreatment.
Metabolic rates of PGI₂, TXA₂, insulin, glucagon and glucose and production of lipid peroxides in the five groups were measured at the points before Pringle's procedure, 5 minutes, 60 minutes and 120 minutes after declamping.
In the group of ischemia without drug administration, the hepatic metabolism of PGI₂, TXA₂, insulin and glucose were decreased after declamping. The metobolism of glucagon, however, was not disturbed by warm ischemia. The production of lipid peroxides increased at 5 minutes after declamping. In the groups of CoQ₁₀, PGE₁ and ON0-3708 pretreatment, changes of PGI₂, TXA₂ and insulin metabolism in the liver were improved, and an increased production of lipid peroxides by warm ischemia was normalized.
This study suggests that CoQ₁₀, PGE₁ and ON0-3708 protect liver damage by warm ischemia as results of improvement of metabolic disturbances of PGI₂, TXA₂, insulin and suppression of lipid peroxides production.

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