[
Abstract]
[
Full Text PDF] （in Japanese / 1573KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 92(2): 118-121, 1991
Original article
CORRELATION OF p150 EXPRESSION AND MALIGNANCY IN GASTRIC CANCERS
The expresslon of proliferation･associated nuclear antigen p105 of gastric carcinomas was studied by multiparameter flow cytometry and immunohistochemical technique. Content of p105-antigen in cancer cells increased with cell cycle progression, and increased more rapidly in cells in late-S phase than in cells in G
0 and early S-phases. Cells in M-phase exhibited a dramatic increase in the amount of the antigen, and the amount of IF intensity of mitotic cells were approximately 5-10-fold greater than that of cells in G
1-and S-phases.Immunohistochemical technique demonstrated that patients with lymph node metastasis are more likely to have high p105 positive rates than node-negative patients. The mean p105 positive rates of aneuploid tumors were significantly higher than those of diploid tumors. These results indicate that the measurement of p105 positive rates may be a powerful prognostic indicator of gastric carcinoma.
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