J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2071KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 91(12): 1796-1807, 1990

Original article

PRESERVATION OF THE ISORATED CANINE HEART FOR 24 HOURS BY RETROGRADE GASEOUS OXYGEN INSUFFLATION

Department of Cardiac Surgery, School of Medicine, Fukuoka University, Fukuoka, Japan

Noritsugu Morishige

Isolated canine hearts were used to evaluate retrograde gaseous oxygen insufflation into the heart at 4℃ compared with simple storage as a method of preservation for 24 hours. The hearts were reperfused with ex vivo apparatus and assessed by left ventricular functional recovery and myocardial energy metabolism. Gas insufflated hearts showed significantly better maintenance of creatine phosphate and adenosine triphosphate content, lower lactate accumulation, and better functional recovery compared with simple storage. However, at the early period of reperfusion, coronary vascular resistance rose significantly in gas-insufflated hearts. Gasinfufflation storage of isolated hearts is capable of maintaining aerobic metabolism, and may be suitable for long distant heart procurement. However, this method may cause gasembolism or any vascular damage which impair the beneficial effects.

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