J.Jpn. Surg. Soc.. 91(11): 1691-1699, 1990
Original article
IMMUNOHISTOCHEMICAL STUDIES ON LEWIS BLOOD GROUP ANTIGENS IN CARCINOMAS AND ADENOMAS OF THE SIGMOID COLON AND RECTUM
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First Department of Surgery, Osaka City University School of Medicine, Osaka, Japan Hiroyuki Motoyoshi |
1. The rate of positive Lewisb staining of adult normal mucosa was 100% in the ascending colon, 100% in the transverse colon, 25% in the sigmoid colon and 30% in the rectum, respectively. The incidence of Lewisb was high in the proximal coion but low in the sigmoid colon and rectum.
2. The rate of positive Lewisb staining was 97% in cancer, 57% in adenoma and 26% in normal mucosa, respectively. The difference between the incidence of positive Lewisb staining in normal mucosa, and those in cancer and adenoma was significant (p<0.01).
3. The rate of positive Lewisb staining was 42% in mild and moderate dysplastic adenoma and 68% in severe dyasplastic adenoma.
There was a significant difference between the percentage of Lewisb staining in mild or moderate dysplastic adenoma and that of severe dysplastic adenoma (p<0.05). The expression of Lewisb antigen correlated with the size of adenoma.
These results suggest that Lewisb antigen has a cancer-associated nature and Lewisb staining might be useful as an indicator of malignant potential of adenoma of the sigmoid colon and rectum.
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