J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 3443KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 91(5): 581-587, 1990

Original article

GROWTH RATE OF EXPERIMENTAL COLONIC CANCER IN RATS

1) Department of Surgery, Showa University School of Medicine, Tokyo, Japan
2) Second Department of Pathology, Showa University School of Medicine, Tokyo, Japan

Akira Tsunoda, Miki Shibusawa1), Masafumi Takimoto2)

Colonic cancers were induced in rats by subcutaneous injection of 1,2-Dimethylhydrazine. Tumor growth patterns were estimated by means of a double contrast barium enema technique. Tumor growth was almost exponential and the average doubling time was 20±5 (m±S.D.) days, at which time three different types of tumor growth patterns: Constant type, decreasing type and reaccelerating type, were noted. Serial double contrast barium enema technique appeared to be an useful method of studying in vivo primary colonic cancer growth patterns in rats.

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