J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2843KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 91(5): 575-580, 1990

Original article

CEA LEVELS OF DRAINING VENOUS BLOOD AND DRAINING-PERI-PHERAL CEA GRADIENT IN COLORECTAL CANCER PATIENTS : CORRELATION WITH POSTOPERATIVE SURVIVAL

1) Department of Surgery, Mitsubishi Kobe Hospital, Kobe, Japan
2) School of Allied Medical Sciences, Kobe University, Kobe, Japan
3) First Department of Surgery, Kobe University School of Medicine, Kobe, Japan

Hiroyuki Deguchi1), Yoshiki Tabuchi2), Yoichi Saitoh3)

Correlation between preoperative CEA levels in draining venous blood (d CEA) and draining-peripheral (d-p) CEA gradient, and postoperative survival of 94 patients with colorectal cancer patients was examined.
The positive rates of d CEA and d-p CEA gradient greater than 5ng/ml (55.9% and 37.2%) in 59 alive patients were significantly (p<0.05) lower than those (77.1% and 57.1%) in 35 patients died of cancer recurrence within 4 years. Survival curve of the patients with positive d CEA and d-p CEA gradient were significantly (p<0.01) lower than those of the patients with negative d CEA and d-p CEA gradient. Survival curve of the patients with d-p CEA gradient greater than 10ng/ml was significantly (p<0.001) lower than that of the gradient less than 10ng/ml, and 4-year survival rates were 37.5% in the former patients and 68.3% in the latter patients.
These results suggest that d CEA and d-p CEA gradient may be used as prognostic indicators of colorectal cancer patients. Clinically, the patients with positive d-p CEA gradient greater than 10ng/ml are necessary to be treated as patients having very poor prognosis.

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