J.Jpn. Surg. Soc.. 88(12): 1718-1730, 1987
Original article
CANINE ORTHOTOPIC LIVER TRANSPLANTATION
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Department of Surgery, The University of Kitasato, Sagamihara, Japan Hisanori Uchida, Kazuhiko Yokota, Koshi Sato, Tsuneo Osakabe, Yoshisuke Nakayama, Tsunemasa Takishima, Koichi Aso |
1) The survival of control dogs without treatment (n＝5) was 10.0±2.9 days (Mean±S.E.), and the survival of dogs treated with mizoribine (n＝15) was 44.6±31.8 days. There was no statistical difference between the two groups. On the other hand, the mean survival of dogs that were initially treated with ciclosporin and were then switched to mizoribine at one to three months after transplantation reached 145.4±70.8days. The survival rate of dogs in the ciclosporin-mizoribine group was significantly greater than that of control group (p＜0.02); and the survival rate of the former group proved also significantly better than that of the mizoribine group at 20 days after transplantation (X2, p＜0.05) ; 2) in cases of acute rejection of the allograft, a gradual increase of the serum bilirubin level with a concomitant rise of S-GPT and alkaline phosphatase was generally observed. For an accurate diagnosis, however, an assessment of the biopsyfindings ofthe allograft is important ; 3) in chronic rejection, one animal developed the selective disappearance of interlobular bile ducts, often referred to as the “vanishing bile duct syndrome” ; and 4) for differential diagnosis of vascular and/or biliary tract complications, specific morphological diagnostic procedures such as vascular and/or biliary tract angiographies are needed.
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