J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1195KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 87(4): 450-455, 1986

Original article

CONGENITAL ABNORMALITIES RELATED TO COAGULATION AND FIBRINOLYTIC SYSTEM, FOUND IN THE PATIENTS WITH VEIN THROMBOSIS OF LOWER EXTREMITIES

Department of Surgery, Jichi Medical School, Tochigi, Japan
*) Institute of Hematology, Jichi Medical School, Tochigi, Japan

Hideki Murayama, Shin-ichiro Manabe*), Michio Matsuda*)

Plasma concentrations of antithrombin III (AT III), plasminogen (Plg), and protein C (PC) were assayed in 28 patients with venous thrombosis of lower extrermities without distinct underlying disorders. Three abnormalities were found in 5 cases (17.8％) in relation to coagulation and fibrinolytic system (3 with congenital AT III deficiency, one each with dysplasminogenemia and congenital PC deficiency).
In the patients with either one of these abnormalities, characteristic features of thrombosis are summarized as follows ; 1. early onset of clinical symptoms. 2. high frequency of superficial vein thrombosis. 3. high recurrence rate. 4. high frequency of pulmonary embolism.

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