J.Jpn. Surg. Soc.. 87(1): 67-78, 1986

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Original article

EXPERIMENTAL STUDY ON CARBOHYDRATE METABOLISM AND PAN-CREATIC ENDOCRINE FUNCTION AFTER PANCREATECTOMY－INFLUENCE OF ISLET ACTIVATING PROTEIN (IAP)

The influences of IAP on the residual pancreatic endocrine function and carbohydrate metabolism after extensive pancreatectomy in the rat were studied with oral glucose tolerance test (OGTT), arginine tolerance test (ATT), and measurement of hepatic glycogen, and hepatic glycolytic enzyme activity, and histological examination, etc.
Wistar male rats weighing around 300g were divided into the groups with IAP treatment and without it, and in the group with IAP treatment IAP 10μg/kg was administered without anesthesia via the tail vein.
In each group 60 and 90％pancreatectomies were performed in accordance with Scow’s method, and the simple laparotomy group was used as control.
1) Slight abnormality of glucose tolerance was shown in 60％ pancreatectomy.
2) The abnormality became worse with time in 90％ pancreatectolny.
3) Glucagon secretion was not damaged markedly even after extensive pancreatectomy.
4) IAP stimulated IRI secretory response and improved glucose tolerance in 60％ pancreatectomy group.
5) IAP showed no effect in 90％ pancreatectomy group.
6) IAP did not stimulate IRG secretory response after pancreatectomy.
7) Hepatic glycolytic enzyme activity was high in the group with IAP treatment.
From the above observation, it has been suggested that IAP may be indicated for the abnormal carbohydrate metabolism after pancreatectomy, if pancreatectomy is not too extensive.

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