J.Jpn. Surg. Soc.. 82(8): 841-849, 1981
Original article
GYNECOMASTIA
-CLINICAL STUDY OF 177 CASES-
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2nd Department of Surgery, Osaka Univ. Med. School Y. Takatsuka, E. Yayoi, Y. Kotuma, M. Kaji, Y. Maeura, T. Aikawa, G. Kosaki |
These cases were classified as follows.
1) Puberal hypertrophy (13 cases)
2) hypertrophy due to hormonal disorders (12 cases)
3) hypertrophy caused by drugs and/or organic diseases (57 cases)
4) idiopathic hypertrophy (95 cases)
It was observed that the most frequent incidence of gynecomastia was semed to occur between the ages of 30 and 40 years.
Of 177 cases, 130 (73.5%) were unilateral and 47 (26.6%) bilateral.
The chief complaint of most patients was of breast mass. One-hundred and forty-one patients had pain or tenderness.
Gynecomastia due to hormonal disorders tends to be bilateral, diffuse and painless.
In studies of urinary 17-OHCS and 17-KS in 46 cases, no apparent abnormalities were found.
Histologically, it was characterized by abundant loose periductal connective tissues with dilatation of the mammary ducts. No lobular formation was observed.
Management of gynecomastia was given:
1) treating the underlining disease, if present
2) hormone therapy using mepitiostane or tamoxifen suitable for idiopathic hypertrophy. (93 % of cases were found responded)
3) operative procedure for the cases due to hormonal disorders.
4) puberal hypertrophy was considered not subjecting to treatment.
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