J.Jpn. Surg. Soc.. 81(11): 1437-1446, 1980
Original article
ENNG(N-ETHYL-N'-NITRO-N-NITROSOGUANIDINE)-INDUCED GASTROINTESTINAL CARCINOGENESIS AND THE SUPPRESSIVE EFFECT OF AN ANTIMETABOLIC AGENT
|
The First Department of Surgery, University of Hokkaido, School of Medicine, Sapporo, Japan (Director: Prof. Yoichi Kasai) Masami Ogita |
Thirty Wistar rats were given ENNG by per os daily for 4 months, followed by another 4-month observation without ENNG.
The incidence of carcinogenesis depended on ENNG concentration. The most effective concentration was 100μg/ml ENNG. The produced carcinomas in the alimentary canal were all adenocarcinomas, including 90% of undifferentiated carcinomas. Carcinomas occurred 80% in stomach, 100% in upper intestine with 40% metastasis in regional lymph nodes and lung. The average number of the tumors on each rat was 5.0±0.5 and their average length was 2.4±0.5cm.
A 5-Fluorouracil(5-FU) and ENNG mixture was given to another 45 rats. In this group, the incidence of carcinogenesis and metastasis was suppressed significantly. The number and the size of the tumors were remarkably decreased. The most effective mixture was 60μg/ml 5-FU and 100μg/ml ENNG.
To read the PDF file you will need Adobe Reader installed on your computer.