J.Jpn. Surg. Soc.. 81(3): 214-225, 1980
Original article
STUDY ON POSTOPERATIVE DEEP VEIN THROMBOSIS
－INCIDENCE AND RISK FACTOR－
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The First Department of Surgery, Gifu University School of Medicine (Director: Prof. Kiyoshi lnada) lsao Okabe |
One hundred and eighty patients undergoing major abdominal surgery were investigated for deep vein thrombosis. All patients underwent postoperative isotopic scanning of the leg using the 125I-fibrinogen technique. Systematic studies on blood coagulation and fibrinolysis were performed on the patients before and after operation.
Measurement of β-thromboglobulin also was done using RIA kit in twenty cases.
Postoperatively 17 of 180 patients developed isotopic evidence of deep vein thrombosis. Thrombosis was unilateral in seven and bilateral in ten. There were no physical signs suggesting thrombosis nor further propagation of thrombi into the popliteal vein or more proximal veins in any cases, although seven of them recieved urokinase treatment immediately after detection of thrombosis in calf veins.
Deep vein thrombosis developed more frequently in patients older than 50 years and in female, and mostly found in patients who had colorectal surgery. All except two had malignant disease. Definite hypercoagulability in thromboelastgram and increase of heparin tolelance were found before operation in patients who had thrombosis compared to those without thrombosis. However, euglobulin lysis time was rather shortened, suggesting increased fibrinolysis.
Effectiveness of 125I-fibrinogen method for detection of vein thrombosis was confirmed.
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