J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text HTML] [Full Text PDF] （in Japanese / 658KB） [PDF: Members Only]

J.Jpn. Surg. Soc.. 124(2): 168-171, 2023

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CURRENT STATUS OF AND PROSPECTS FOR CLOSED-LOOP ARTIFICIAL PANCREAS THERAPY

1) Department of Surgery, Kochi Medical School, Nankoku, Japan
2) Kochi Medical School Hospital, Kochi Medical School, Nankoku, Japan

Hiroyuki Kitagawa1)2), Masaya Munekage1), Hiromichi Maeda1), Tsutomu Namikawa1), Kazuhiro Hanazaki1)2)

Blood glucose management in perioperative and critically ill patients involves the risk of hypoglycemia associated with continuous insulin administration. The closed-loop artificial pancreas allows real-time measurement of blood glucose levels, high target glucose achievement rates, and avoidance of severe hypoglycemia and minimization of blood glucose variability. Small portable artificial pancreas therapy is used for type 1 diabetes patients, although these systems calculate blood glucose levels from subcutaneous tissue fluid and have a time lag with plasma glucose concentrations. Therefore, a bedside-type closed-loop artificial pancreas is suitable for perioperative management and critical care patients. Current guidelines only recommend blood glucose levels to prevent perioperative infectious complications, but in the future, continuous blood glucose data obtained through the closed-loop artificial pancreas and artificial intelligence should be used to establish new indices such as time ranges.

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