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J.Jpn. Surg. Soc.. 107(4): 182-186, 2006


Feature topic

PRE- AND POST‐OPERATIVE CHEMORADIATION THERAPIES FOR PANCREATIC CANCERS

1) Departments of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases
2) Radiation Therapy, Osaka Medical Center for Cancer and Cardiovascular Diseases

Osamu Ishikawa1), Hiroaki Ohigashi1), Hidetoshi Eguchi1), Terumasa Yamada1), Yo Sasaki1), Shingi Imaoka1), Kinji Nishiyama2)

Due to a high incidence of local recurrence, the long-term outcome after resection of locally advanced pancreatic cancer is still pessimistic. Many previous reports showed that locoregional control was partly improved by intraoperative radiation or postoperative chemoradiation, while others suggested its insufficient effects for patients with R1- or R2-resections. Therefore some recent authors have recommended preoperative chemoradiation for more promising results in advanced pancreatic cancer. Since patient survival is influenced not only by local control but also by distant(the liver is the most common)metastases, we should develop other strategies that can prevent liver metastases, in addition to the combination of chemoradiation with surgery.


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