J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 484KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 104(6): 443-446, 2003

Feature topic

MOLECULAR FACTORS PROMOTING CARCINOGENESIS AND MALIGNANT BEHAVIOR OF INTRADUCTAL PAPILLARY MUCINOUS TUMORS

Department of Surgery-II, Yokohama City University, School of Medicine, Yokohama, Japan

Yasushi Ichikawa, Michio Ueda, Yasuhiko Miura, Satoshi Kunihiro, Takashi Ishikawa, Itaru Endo, Hitoshi Sekido, Hiroshi Shimada

Many molecular factors related to the carcinogenesis and malignant behavior of pancreatic cancer were identified by investigation of intraductal papillary mucinous tumors (IPMTs). Molecules controlling the G1/S phase, such as p53, p21, p61, and cyclin D1, tumor suppressors including DPC-4, and many other factors such as MUC-1/2 contribute to the promotion of the malignant behavior of IPMTs. They will be important molecular targets for the radical treatment of pancreatic cancer.

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