J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1823KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 99(6): 379-384, 1998

Feature topic

ABERRANT CRYPT FOCI AS BIOMARKERS IN CHEMOPREVENTION FOR COLORECTAL CANCER

1) The Forth Department of lnternal Medicine, School of Medicine, Sapporo Medical University, Sapporo, Japan
2) Deparment of Gastroenterology, National Sapporo Hospital, Sapporo, Japan
3) Department of Gastroenterology, Shinnittetsu Muroran Hospital, Muroran, Japan

Shinichi Katsuki1), Masao Oui1), Tetsuji Takayama1), Yasuo Takahashi2), Shuichi Nojiri3), Yoshiro Niitsu1)

Aberrant crypt foci (ACF) are small lesions identiafiable in whole-mount preperations of norrnalappearing human colonic mucosa with the aid of methyleneblue staining under stereoscopic microscope. Highly frequent mutations of K-ras genes were found, and increased proliferative activities were also observed. Therefore, K-ras gene mutation may have some role in formation of ACF. Using rat experimentai model, formation of ACF was shown to be enhanced by cancer promoters (such as secondary bile acids), and to be suppressed by chemopreventive agents (deoxycholic acid and aspirin). Based on these findings, ACF are considered to be precursors of colon cancer. We demonstrated that ACF are the precursors of adenomacarcinoma sequence. Moreover, we showed that ACF may be suitable biomarkers of chemopreventive agents for colon cancers.

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