J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 3480KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 98(8): 706-712, 1997

Editorial

NEW ASPECTS IN THE LIVER REGENERATION FOLLOWING PARTIAL HEPATECTOMY

1) The First Department of Surgery, Nigata University School of Medicine, Niigata, Japan
2) Department of Transplantation Immunology Faculty of Medicine, Kyoto University, Kyoto, Japan

Yoshinobu Sato1)2), Kazuhiro Tsukada1), Koichi Tanaka2), Katsuyoshi Hatakeyama1)

We demonstrated the new two concepts for the liver regeneration after partial hepatectomy (PHx). The first is immunological findings in the regenerating liver. Th1 type T cells, which produce IFNγ, and extrathymic T cells may pIay an important role in immunological control system of liver regeneration after PHx on the basis of the cellular immunity restricted by MHC class I and II molecules. The second is the mechanism of “on and off” on liver regeneration after PHx. Portal pressure, which reflecting wall shear stress of sinusoid, may trigger the liver regeneration and control the Iiver volume after PHx. There are two type of intrahepatic Ieukocytes ; one type, would tend to stay associated with SEC, while the other would not. Therefore shear stress may have a great influence on the leukocytes-sinusoidal endothelial cells (SEC) adhesion immediately after partial hepatectomy.

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