[Abstract] [Full Text PDF] (in Japanese / 1069KB) [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 98(4): 431-437, 1997


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NON-SURGICAL THERAPY FOR ULCERATIVE COLITIS

3rd Department of Internal Medicine, School of Medicine, Niigata University, Niigata, Japan

Hitoshi Asakura, Koji Suzuki, Terasu Honma

Ulcerative colitis involving primarily the mucosa of the colon and rectum is a diffuse and nonspecific inflammatory disease. Immunocompetent cells infiltrating in the inflammed mucosa are mainly lymphocytes, macrophages and neutrophils. These activated cells produce proinflammatory cytokines such as IL-1, IL-6, IL-8 and TNFα and inflammatory activators such as PAF, leukotriene, prostaglandins, free radicals and proteases, resulting in acute on chronic states. Non-surgical therapy for ulcerative colitis includes basic medical therapy with sulfasulphapyridine, 5-ASA, corticosteroids and immune suppressive drugs as well as new therapies, which are leukocytapheresis, granulocytapheresis, anticytokine therapy with antiTNFα monoclonal antibody, IL-1ra and IL-10, intravenous treatment of massive immunoglobulins and transdermal nicotine therapy.


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