J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1831KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 95(11): 838-842, 1994

Case report

A CASE OF RUPTURED HEPATOCELLULAR CARCINOMA WITH RAPID GROWTH AFTER THE INTERFERON THERAPY IN CHRONIC HEPATITIS

Department of Surgery, Kaizu Medical Association Hospital, Gifu, Japan

Atsuyoshi Onitsuka, Hiroyuki Yasuda, Naoki Yamada, Tomoyuki Miyata, Toshimi Kachi

A 75-year-old man who had had a long history of chronic hepatitis C virus liver disease underwent interferon(IFN)therapy for three months. After three months of the last IFN injection, he presented with a sudden attack of epigastralgia. Abdominal US and CT revealed a tumor about 9×10 cm in the right lobe of the liver. Serum AFP level was 8,499 ng/ml. Spontaneous hemoperitoneum due to ruptured hepatocellular carcinoma(HCC)was suspected. Hepatectomy was carried out on 35 days postembolization. Pathological examination revealed HCC of trabecular type. Although the relation between the rapid growth and IFN is not clear, US examination should be performed once a month for the patient.

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