J.Jpn. Surg. Soc.. 95(4): 271-281, 1994

---

Original article

EARLY DIAGNOSIS OF ACUTE REJECTION IN SINGLE LUNG TRANSPLANTATION FROM THE STANDPOINT OF PULMONARY HEMODYNAMICS

The aim of this study is to clarify the early phase of acute rejection of the single lung transplantation by the pulmonary hemodynamics. Twenty dogs were divided into 3 groups {Group I (6 dogs): Modified autotransplantation, Group II (6): Allotransplantation without immunosuppression, Group III (8): Allotransplantation with immunosuppression (CYA 10mg/kg, AZ 2mg/kg)}. Cardiac output (CO) and pulmonary arterial (PA) flow of the transplanted lung were measured continuously using Doppler flow method. In Group I, PA How was maintained at about 40% of CO for 2 weeks. However, in Group II, PA flwo gradually decreased to 15% of CO on the 7th postoperative day (POC) and all animals died of rejection within 2 weeks after surgery. In Group III, PA flow decreased to 20% of CO on the 1st POD but, then increased gradually to 38% on the 14th POD. When rejection was induced by discontinuation of CYA and AZ, PA fiow decreased to below 13% of CO within 3.7 days (mean) and perivascular cuffing was found in open biopsy, although findings on chest X-ray films remained unchanged. PA flow returned to 40% within 4.3 days (mean) by injecting methylpredonisolone for 3 days. In conclusion, the measurement of pulmonary hemodinamics might be useful in the early diagnosis of acute rejection after single lung trnasplantation.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.