[
Abstract]
[
Full Text PDF] （in Japanese / 539KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 94(8): 832-839, 1993
Original article
RELATIONSHIP BETWEEN ASEPTIC NECROSIS OF FEMORAL HEAD BONE AND IMMUNOSUPPRESSION THERAPY, ESPECIALLY CsA ADMINISTRATION
We reviewed 224 patients, who underwent kidney transplantation to investigate relationship between asepticnecrosis (AN) and administration of steroid, Cyclospolin A (CsA), body weight gain. We classified patients into 4 groups by the type of immunosuppressant: the AP group had received Azathioprine (AZ)+ Prednisolone(Pre); the CP group, CsA + Pre; the ACP group, AZ+ CsA + Pre; and others. There were total 24 AN patients (10.7%). Theincidences of AN is 18% in the CP group, 9.3% in the AP group and 0% in the ACP group. In the AP group, weightgain at 1 and 2 month after transplantation and cumulative steroid dose at 3, 4, 5 and 6 month after transplantationcorrelated with AN. In the patients with AN of the CP and ACP groups, CsA doses per kilogram of body werehigher than those in patients without AN at 5, 6 and 12 month after transplantation. In the CP group, theincidence of AN is significantly higher, and administration dose of CsA was higher than that in the ACP group. However steroid dose and body weight gain were lower in the CP group. Therefore AN was associatedwith CsA in the CP group. In contrast, AN corelated with weight gain and early high cumulative steroid doseadministration in the AP group.
To read the PDF file you will need Adobe Reader installed on your computer.