[
Abstract]
[
Full Text PDF] （in Japanese / 632KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 94(8): 809-815, 1993
Original article
EXPERIMENTAL STUDY ON THE EFFECTS OF ENDOTOXEMIA AS A RETARDATION-FACTOR INFLUENCING ON THE DECREASE OF SERUM BILIRUBIN AFTER THE RELIEF OF OBSTRUCTIVE JAUNDICE
I examined the effects of endotoxemia influencing on obstructive jaundice and the decrease of serum bilirubinafter the relief of it. Experimental obstructive jaundice and its alleviation by external biliary drainage was madein Donryu-rats. Serum bilirubin was higher (p＜0.01) in the group treated by continuous infusion of low-dose endotoxin (LPS E. coli 0111 : B
4, 6μg/hr/100gBW) during 72 hours biliary obstruction (10.48±1.54mg/dl) than in thecontrol group (6.76±0.71mg/dl). After the relief of biliary obstruction, 4 kinds of experimental conditions were setup as follows: CONTROL; infusion of sterile saline, ET ; continuous infusion of low-dose endotoxin, ET + UDCA; continuous infusion of endotoxin and ursodeoxycholic acid (UDCA, 10mg/hr/100gBW) through another intravenoustube simultaneously, ET+ MP; continuous infusion of endotoxin after one-shot injection of methylpredonisolone (MP, 3mg/100gBW). Serum bilirubin 7.5 hours after the relief of biliary obstruction was as follows : CONTROL : 0.48±0.18mg/dl, ET: 3.41±1.13mg/dl, ET + UDCA: 2.80±1.28mg/dl, ET + MP: 1.18±0.50mg/dl. ET-group showed retardation of the decrease of serum bilirubin (p＜0.01). MP showed improvement of the impaired decreasing rate of serum bilirubin by endotoxemia (p＜0.01). Bile-output from the external biliary drainage after the relief of biliary obstruction was decreased significantly in the ET-group. ET+UDCA-group showed remarkable increase of the bile-output, but no increase of excretion of bilirubin in the bile compared with ET-group. While ET+ MP-group showed improvement of the bile-output and increase of excretion of bilirubin in the bile compared with ET-group. ET or its related factors may cause biliary stasis and hepatocellular dysfunction, so that may protract jaundice.
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