J.Jpn. Surg. Soc.. 94(6): 637-644, 1993

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Original article

THE INFLUENCE OF CHOLESTEROL FEEDING ON THE ANASTOMOTIC REGION OF THE INDUCED ATHROSCLEROTIC RABBIT VESSELS
―ESPECIALLY ON THE LATE OCCLUSIVE PROCESS―

Late occlusive complication of implanted graft may occur 6 months to 5 years after operation. The most frequent cause of this condition is considered to be an intimal thickening at the anastomotic sites. The relationship between this intimal thickening and cholesterol feeding in rabbits was investigated. Twenty eight male New Zealand White Rabbits were assigned following 4 groups.
Group 1: given 0.1% cholesterol containing rabbit pellets after denudation of endothelium
Group 2: given standard laboratory rabbit pellets after denudation
Group 3: given 0.1 % cholesterol rabbit pellets without denudation
Group 4: given standard rabbit pellets without denudation
Anterior half of infrarenal abdominal aorta of all rabbits was incised and then continuous over and over suture was carried out. Three months later, rabbits were killed and specimens were obtained.
In group 1, 3 specimens out of 7 were found significant intimal thickening near anastomosis, whereas, in group 2 specimens showed regular thickening which seemed to be affected by denudation of endothelium. In group 3, intimal thickening localized only near anastomosis was found. From these results, we concluded intimal thickening at the anastomotic sites can be considered as the initial stage of atherosclerosis and cholesterol would be one of the important factors which promote this thickening.

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