J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 3430KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 94(2): 119-127, 1993

Original article

RADIOIMMUNODETECTION OF COLORECTAL CANCER, USING ANTI-CEA MONOCLONAL ANTIBODY CEA102: EXPERIENCE OF 20 CASES

1) Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan
2) Department of Radiology, Nagoya University School of Medicine, Nagoya, Japan
3) Department of Gastrointestinal Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
4) Department of Surgery, Nagoya National Hospital, Nagoya, Japan

Kazuyuki Murakami1), Tadashi Watanabe1), Masanori Tadokoro2), Junichi Sakamoto3), Hiroki Murayama4), Kimio Wada1), Sadayuki Sakuma2), Hiroshi Takagi1)

The monoclonal antibody CEA 102 against carcinoembryonic antigen was produced by immunization with purified CEA, and used as a radiotracer for the imaging of colorectal cancer. CEA102 was labeled with 131I by the chloramine-T or the Iodogen method, and administered i.v. to 20 patients with liver metastases, local recurrences, and/or primary tumors. Planar scintigraphy was performed during 5 or 6 postinfusion days. Hypersensitivity reactions such as fever and chill occurred in 4 patients, but no side effects were noted after endotoxin was excluded. Overall sensitivity was 71.4% (primary tumor 4/4, liver metastasis 5/6, lymph node metastasis 1/1, local recurrence 5/10), and no false positive was observed. In the cases of local recurrences, this method was useful to distinguish postoperative fibrosis from local recurrence. These results revealed that radiolabeled CEA102 has a great potential in qualitative diagnosis of colorectal cancer.

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