J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2348KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 93(7): 684-690, 1992

Original article

AN EXPERIMENTAL STUDY ON THE REJECTION PHENOMENON OF MULTIVISCERAL　ALLOGRAFTS IN PIGS

1) Second Department of Surgery, Kagoshima University, Faculty of Medicine, Kagoshima, Japan
2) First Department of Pathology, Kagoshima University, Faculty of Medicine, Kagoshima, Japan

Tsutomu Yamauchi1), Nobuo Hamada1), Teruo Kumagai1), Akira Ikoma1), Koki Tanaka1), Akira Taira1), Hiromi Yoshida2)

Multivisceral allografts including the liver, pancreas and gastrointestinal tract were transplanted in 10 pigs. Eight of them survived for 7 to 21 days. Histopathological changes were studied in the liver, pancreas and gastrointestinal tract. An en bloc transplantation revealed no particular course after transplantation than those individual organ transplantation. The status of rejection was assessed by our histological criteria, which are divided into 5 grades about the liver and 4 grades about other organs according to the severity of the acute rejection. A higher grade of rejection was apparently in the small and large intestine especially after the 10th posttransplanted day (Grade II to III in the small and large intestine v. Grade 0 to II in the liver, stomach and pancreas). The study suggests the existence of organspecific susceptibility to rejection in multivisceral organ transplantation.

<< To previous pageTo next page >>

To read the PDF file you will need Adobe Reader installed on your computer.