J.Jpn. Surg. Soc.. 93(1): 36-42, 1992

---

Original article

CHANGES OF THE INSULIN AND GLUCAGON RECEPTORS IN BILE-DUCT LIGATED RATS

The specific bindings of insulin and glucagon to 40000g pellets including hepatic plasma membrane were measured at 1, 2 or 4 weeks after bile-duct ligation or sham operation in rats.
At 1 week after operation, insulin bindings were similar in both bile-duct ligated and control rats, however, glucagon binding in bile-duct ligated rats (30.1±5.99%) was significantly (p＜0.01) lower than that in control rats (42.8±8.13%).
At 2 and 4 weeks after operation, insulin bindings in bile-duct ligated rats (2 weeks: 35.2±3.32%, 4 weeks: 32.3±4.62%) were significantly (p＜0.05) lower than those in control rats (2 weeks: 39.7±5.12%, 4 weeks: 38.4±3.85%).
Therefore, glucagon bindings in bile-duct ligated rats (2 weeks: 26.3±4.32%, 4 weeks: 26.9±4.06%) were significantly (p＜0.01) lower than those in control rats (2 weeks: 42.0±3.95%, 4 weeks: 45.3±4.29%). Decrease of insulin bindings, however, was less than that of glucagon bindings.
Changes of the insulin and glucagon receptors on the hepatic plasma membrane suggested a reason for a disturbance of carbohydrate metabolism in the liver cell with obstructive jaundice.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.