J.Jpn. Surg. Soc.. 92(11): 1545-1551, 1991
Original article
THE EFFECT OF HUMAN GROWTH HORMONE ON PROTEIN METABOLISM
IN THE SURGICALLY STRESSED STATE
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1) First Department of Surgery, Chiba University Medical School, Chiba, Japan Kazuya Takagi1), Tsuguhiko Tashiro1), Yoshiya Mashima1), Hideo Yamamori1), Katsuji Okui1), Isao Ito2) |
In the experimental study, thirty one male SD rats receiving TPN were divided into 2 groups (control group＆ HGH group). Cumulative nitrogen balance after burn in HGH group was significantly higher than in control group. (p＜0.05) Rates of whole body protein turnover (Q), togeher with those of synthesis (S) and breakdown (B) were significantly higher in HGH group than in control group. (p＜0.01) Nitrogen balance significantly correlated with urinary total catecholamine excretion in both groups. (p＜0.01) The difference of correlations of nitrogen balance to urinary total catecholamine excretion between two groups was statistically significant (p＜0.01) when compared by analysis of covariance.
In the clinical study, 12 patients after sub-total esophagectomy receiving TPN were divided into 2 groups (control group＆HGH group). Cumulative nitrogen balance after operation in HGH group was significantly higher than in control group. (p＜0.01) Q, S, and B were higher in HGH group than in control group. Increase of S was statistically significant. (p＜0.01)
These results indicate that HGH may be greatly beneficial in improving protein metabolism in the surgically stressed state.
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