J.Jpn. Surg. Soc.. 92(10): 1480-1485, 1991
Original article
ENHANCEMENT OF SELECTIVE DRUG ACCUMULATION AND RETENTION IN NORMAL AND REGENERATING LIVER BY THE USE OF LlPIODOL lN PORTAL VENOUS INFUSION IN RATS
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First Department of Surgery, Chiba University, School of Medicine, Chiba, Japan Hiroyuki Suzuki, Masaru Miyazaki, Katsuhiro Iinuma, Ikuo Udagawa, Hisao Koshikawa, Hiroshi Ito, Katsuji Okui |
Total concentration of Aclarubicin (ACR) and its metabolites in liver tissue was higher in ACR+LP portal infusion group than in ACR portal infusion group both in normal and regenerating livers. In regenerating liver, concentration of active metabolites of ACR was higher in ACR portal infusion group than in ACR peripheral infusion group. Much higher concentration was found in ACR+LP portal infusion group.
Histologic examination revealed more toxic effect on regenerating liver in ACR portal infusion group than in ACR+LP portal infusion group. Oil red staining demonstrated the retention of lipiodul more than 7 days following intraportal infusion in regenerating liver tissue.
This study confirms that the ACR+LP portal infusion induces selective accumulation and long-term retention in normal and regenerating liver tissue, and may enhance the antitumor effect of drugs.
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