J.Jpn. Surg. Soc.. 92(10): 1469-1479, 1991
Original article
DNA CONTENT AND c-erbB-2 ONCOPROTEIN EXPRESSION IN HEPATIC METASTASES FROM COLORECTAL CARCINOMA
―IN RELATION TO CLINICOPATHOLOGIC FINDINGS AND PROGNOSIS―
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The First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan Kazuyoshi Omori |
The frequency of aneuploidy and positive staining of c-erbB-2 in primary tumor with hepatie metastases were significantly higher compared with those without hepatic metastases (p＜0.05). There were significant correlations between diameter of metastases and DNA ploidy pattern of themetastases and between metachronous metastases, degree of metastases, vessel involvement and DNA ploidy pattern of the primary tumor.
Positive staining of c-erbB-2 was detected more frequently with the advancement of depth of tumor invasion. There was no significant coreelation between DNA ploidy pattern and c-erbB-2 expression.
In the survival of patients whose primary tumor and hepatic metastases were resected, it was shown that DNA ploidy pattern of metastases was the most important independent prognostic factor. Expression of c-erbB-2 in primary tumor predicted the hepatic metastases.
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