J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2413KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 92(10): 1419-1425, 1991

Original article

POLYMORPHONUCLEAR LEUKOCYTE ELASTASE (PMNE) LEVELS IN SURGICAL PATIENTS WITH POSTOPERATIVE INFECTIONS

First Department of Surgery, Yamaguchi University, Ube, Japan

Norichika Matsui, Nobuyoshi Morita, Shinji Noshima, Tadahiko Enoki, Fumihito Aikawa, Tetsuro Kobayashi, Kensuke Esato

To study the role of lysozomal enzyme released from polymorphonuclear leukocytes during postoperative infections, plasma levels of PMNE were measured serially in 53 patients who underwent digestive surgery.
The patients were devided into two groups, 18 patients with postoperative infections (infected group), and 35 patients without infections (non-infected group). The PMNE levels in the non-infected group elevated during one week with peak value in one postoperative day, but returned to preoperative levels in two weeks. The levels of fibronectin (FN), C3, C4 and antithrombin III (ATIII) were decreased after surgery, but returned within seven postoperative days.
On the contrary, the PMNE levels in the infected group remained high two weeks after operations and elevated higher than those of non-infected group before clinical signs of infections. In infected group, the levels of FN and ATIII were significently decreased two weeks after surgery, compared to those of non-infected group. Correlations were demonstrated between the amotint of PMNE and the decrease in the levels of FN and ATIII.
It is suggested PMNE might play a role in the pathobiochemical alterations including of acceleration of coagulation during postoperative infections. The measurement of the levels of PMNE in the postoperative course seems to be an useful index to early diagnosis of postoperative infections.

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