J.Jpn. Surg. Soc.. 92(8): 907-912, 1991

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Original article

DISSEMINATED INTRAVASCULAR COAGULATION IN THE EARLY STAGE AFTER SEVERE BURN：THE ROLE OF EXCESSIVE THROMBIN GENERATION

The pathogenesis of disseminated intravascular coagulation(DIC)in the early stage after burn inj ury remains still unclear. We investigated 12 burn injured patients by serial determination of anti-thrombin III (AT･III) activities and thrombin･antithrombin III complex (TAT) levels. Of these patients,4developed DIC (DIC group) and the others had no hematological complications (non-DIC group).
The mean levels of TAT increased markedly and peaked at 6hr, the increment being more pronounced in DIC group (p＜0.001). A significant correlation was recognized between TAT and Burn lndex (r=0.871, p＜0.001). We also observed low AT-III activities those inversely related to Burn Index (r=0.875, p＜0.001), whereas closely correlated with serum albumin levels (r=0.864, p＜0.001), suggesting that this depression might be caused by both massive infusion and shifts of plasma into the extravascular space rather than consumptlon.
These findings suggest that massive thrombin generation and decrease of anticoagulant activity, correlated to the severity of burns, might concurrently develop. Non-DIC group may remain to latent activation of coagulation cascade where anticoagulants could inactivate thrombin generated. This compensatory mechansim may fail in severe burn patients who have Burn Index Of more than 90, developing DIC with high levels of TAT (316.3±104.5ng/ml) and low AT-III activities (19.5±8.7%).

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