[
Abstract]
[
Full Text PDF] （in Japanese / 4759KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 92(7): 813-819, 1991
Original article
THE EXPRESSION OF THE BLOOD RELATED ANTIGENS IN INTESTINAL METAPLASIA OF THE STOMACH HAD IN GASTRIC CANCER
The monoclonal antibodies detecting blood group related antigens of the Lewis systems have been used to define the immunoanatomic distribution of these antigens within the normal gastric mucosa and in gastric cancer tissues. In this study we analysed the presence of these antigens in histologically intestinal metaplasia of the stomach by the immunoperoxidase method. In normal gastric mucosa, Lewis
b was distinctly expressed in normal foveolar epithelia and Lewis
a was present in foveolar epithelia in half of the cases. Lewis
x and Lewis
y were detected in deep gastric glands. In intestinal metaplasia, more pronounced expression of Lewis
a and decreased expression of Lewis
b were observed. Lewis
x and Lewis
y were absent in most specimens of intestinal metaplasia. These pattern of expression of Lewis antigens in intestinal metaplasia were very similar to those observed in well and moderately differentiated adenocarcinomas of the stomach. These results indicate that well and moderately differentiated adenocarcinomas of the stomach have very similar character with the intestinal metaplasia in terms of the Lewis blood group antigen expression.
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