J.Jpn. Surg. Soc.. 92(7): 775-784, 1991

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Original article

5-FU CONCENTRATION IN THE TISSUE OF GASTRIC CANCER, AND EVALUATION OF CANCER CHEMOTHERAPY WITH ANGIOTENSIN-Ⅱ

A preferable route for administration of anti-cancer drugs together with angiotensin-Ⅱ (AT-Ⅱ) was examined by measuring the tissue concentration of drugs in resected specimens. Twenty five patients with gastric cancer were randomly divided into five groups, and 5-FU (250 mg) was given with or without AT-Ⅱ intraoperatively.
Group A; i.v. 5-FU alone (n=5), Group B; i.v. 5-FU with AT-Ⅱ (n=5), Group C; i.a. 5-FU alone (n=5), Group D; i.a. 5-FU with i.v. AT-Ⅱ (n=5) and Group E; i.a. 5-FU with AT-Ⅱ (n=5). 5-FU level in regional lymph nodes was statistically higher -in Group D compared to other groups, while in tumor tissues it was markedly higher in Group E. The ratio of 5-FU level in tumor tissues to normal tissues (TIN) was higher in Groups D and E.
In patients with advanced malignancies, respo!lse rates were 17% in i.v. anti-cancer drugs with AT-Ⅱ group, 41% in i.a. anti-cancer drugs with i.v. AT-Ⅱ group and 24% in i.a. anti-cancer drugs with AT-Ⅱ group. Median survival time for each group were 6.3 months, 9.6 months and 14.2 months, respectively.
It is concluded that intra-arterial infusion chemotherapy together with AT-Ⅱ can be an effective treatment for advanced malignancies.

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