J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1461KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 92(4): 397-400, 1991

Original article

DNA PLOIDY IN SUBMUCOSAL CANCER OF THE STOMACH AND ITS
RELATIONSHIP TO LYMPH NODE METASTASIS

1) Department of Surgery, Gunma Cancer Center Hospital, Mebashi, Japan
2) First Department of Surgery, Gunma University School of Medicine, Mebashi, Japan
3) Department of Pathology, Gunma Cancer Center Hospital, Mebashi, Japan
4) Second Department of Pathology, Gunma University School of Medicine, Mebashi, Japan

Tetsuo Hashizume1), Takehiro Yamaura2), Takahiro Fukuda1), Shiro Sugihara3), Takashi Nakajima4), Yukio Nagamachi2)

The relationship between DNA ploidy and lymph node metastasis was determined in 40 cases of gastric cancer confined to the submucosa(with lymph node metastasis 20 cases and without 20 cases). The DNA ploidy patterns were classified as follows; Type D, Type A1 and Type A2. Of the 20 cases with lymph node metastasis, 1 was Type D, 7 were Type A1 and 12 were Type A2. The likelihood of lymph node metastasis was 12.5% (1/8) for Type D, 43.8% (7/16) for Type A1 and 75.0% (12/16) for Type A2. It is concluded that although gastric cancer confined to the submucosa is classified as early one, analysis of DNA content places such tumors with lymph node metastasis into the advanced cancer category.

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