[
Abstract]
[
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[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 92(3): 320-330, 1991
Original article
EXPRESSION AND CLINICAL SIGNIFICANCE OF TYPE-1 BLOOD GROUP ANTIGENS(Lea, Leb, CA19-9) IN COLORECTAL CANCER―COMPARISION WITH CEA―
The immunohistochemical analysis using the monoclonal antibodies to the blood group associated antigens Le
a, Le
b, CA19-9, and CEA, were performed on the tissues of the colorectal cancers, adenomas, normal mucosae and distant metastatic lesions, to determine whether the given degree of expression have some relation to the prognosis of patients or the potential of metastasis. We also analysed the serum levels of CA19-9 and CEA by RIA and compared them with the results of immunopathology. The more pronouced expression of CEA, Le
a, Le
b, and CA19-9 was observed in proportion to the progress of the cancer. In those cases of immunohistochemically Le
a negative results in tissues, CA19-9 was not detected either in the serum level nor in tissue sections, therefore all cases of Le
a negative results were eliminated in the evaluation of the clinical significance of CA19-9. Positive expression of CA19-9 in tissue of cancer indicated a poor prognosis of the patient and high risk of distant metastasis. Higher intensity of staining was observed in hepatic metastasis, in comparison with the primary lesion. These studies demonstrated that immunohistochemical analysis of CA19-9 and blood group antigens in useful tool for evaluation of prognosis and risk of metastasis in colorectal cancer.
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