J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 3492KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 92(3): 313-319, 1991

Original article

THE USEFULNESS OF NUCLEOLAR ORGANIZER REGIONS IN DIAGNOSIS OF COLONIC EPITHELITAL NEOPLASIA

*) The First Department of Pathology, Niigata University School of Medicine, Niigata, Japan
**) The First Department of Surgery, Niigata University School of Medicine, Niigata, Japan

Tadasu Chida*), Hidenobu Watanabe*), Yoichi Ajioka*), Terasu Homma*), Katsuyoshi Hatakeyama**), Terukazu Muto**)

The Ag-NORs technique, staining nucleolar organizer regions, was performed on 23 areas of colonic normal mucosa, 17 adenomas with low grade atypical and 8 adenocarcinoma invading submucosa, to examine its possibility of application to the pathological diagnosis of colonic epithelial neoplasia.
In normal colonic gland, the average number of Ag-NORs per 1 nucleus in cells of lower two-thirds showed significantly higher value (p＜0.01) than higher one-third, and the mean cross-section area per 1 Ag-NOR in lower two-thirds showed a tendency to be larger than higher one-third. This results suggested that there was a positive correlation between the proliferative activity of cells and the number and size of Ag-NORs.
Acomparison of normal gland, adenoma and adenocarcinoma showed that the mean cross-section area of Ag-NORs correlated positively to their histological grade of atypia, but the average number did not. However using these two parameters, these three lesions had a tendency to be discriminated respectively at the average Ag-NORs number of 2.8 dots and the area of 2μm2.
These results suggested that the Ag-NORs technique was expected to be a useful method for histopathological diagnosis of colonic epithelial meoplasia.

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