J.Jpn. Surg. Soc.. 92(3): 303-307, 1991
Original article
EXPRESSION OF PROLIFERATION ASSOCIATED NUCLEAR ANTIGEN P-105 IN HUMAN GASTRIC CANCERS: AS A NEW MARKER FOR METASTASIS
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Second Department of Surgery, Kanazawa University School of Medicine, Kanazawa, Japan Shigekazu Oyama, Yutaka Yonemura, Koichiro Tsugawa, Yoshinobu Kimura, Toru Kamata, Koichi Miwa, Itsuo Miyazaki |
Expression of P-105 was observed abundantly in cancer, about four times than normal mucosa, but little in normal gastric mucosa. We evaluated the expression of P-105 in cancer as P-105 intensity : mean FITC levels of G0G1 of the cancer cells/those of normal cells. The P-105 intensity did not correlate with DNA index or S-phase fraction. Furthermore, it did not correlate with histologic type, stromal type, infiltrating type, and gross appearance. However, P-105 intensity was sigrtificantly higher in the patients with hepatic metastasis, and lower in those with peritoneal dissemination than those without metastasis, respectively.
From the results, it was supposed that P-105 intensity might be a useful indicator for metastatic type different from those previously reported in human gastric cancers.
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