J.Jpn. Surg. Soc.. 92(2): 167-174, 1991

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Original article

EFFECTS OF MITOCHONDRIAL LIPOPEROXIDATION ON LIVER REGENERATION AFTER PARTIAL HEPATECTOMY OF THE CIRRHOTIC RAT LIVER

Lipoperoxide levels in mitochondrial fraction and mitochondrial respiratory activity during hepatic regeneration were studied serially in normal (N) and cirrhotic (C) rats following one-third (I) or two-third (II) partial hepatectomy.
Recovery of liver weight after 14 days was about 90% in each group except C-II group, in which it was 71.3%.
ATP synthetic activity (ATP-S) was always higher in N-II group than N-I which reached maximum on the first postoperative day (POD) and returned to the preoperative levels on the 14th POD. Lipoperoxide peak value of N-II group was obtained sooner than that of N-I group, in addition the peak value of N-II group was higher than that of the N-I group.
ATP-S of C-II group reached maximum levels on the third POD and thereafter decreased progressively. In contrast, ATP-S of C-I group returned to preoperative level on the 14th POD. Peak lipoperoxide levels were obtained on the first POD in both groups, but that of C-II group was 1.6 times higher than that of C-1. Moreover, it was observed that inhibition of lipoperoxidation by α-tocopherol administration improved respiratory actlvlty significantly.
From these results it can be said that hepatectomy-induced lipoperoxidation in massive resection of the cirrhotic liver may inhibit activation of mitochondrial respiration and hepatic regeneration.

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