J.Jpn. Surg. Soc.. 91(7): 875-882, 1990
Original article
SEX HORMONE-BINDING GLOBULIN IN BREAST CANCER
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The Second Department of Surgery, School of Medicine, The University of Tokushima, Tokushima, Japan Yoshihisa Suminaga, Tadaoki Morimoto, Kansei Komaki, Toshiaki Mori, Yasumasa Monden |
The results are as follows:
1) Although the serum SHBG concentration showed no significant difference between the breast cancer group and the healthy control group, the serum SHBG concentration in postmenopause was significantly higher in the breast cancer group（63.8±31.2nmol/ml/ml; mean±S.D.) than in the healthy control group（40.1±15.4nmol/ml).
2) Subsequently in the postmenopausal breast cancer group, the serum SHBG concentration was significantly higher in the estrogen receptor（ER)-negative cancer group（97.8±12.7nmol/ml) than in the ER-positive cancer group（55.8±32.1nol/ml).
3) No significant relationships were showed between the serum SHBG concentration and obesity or serum estradiol concentration in postmenopausal patients.
4) The serum SHBG concentration showed significant decrease 3 months after radical operation for breast cancer in postmenopausal patients.
These results suggest the possibility of the SHBG synthesis in breast cancer tissue.
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