J.Jpn. Surg. Soc.. 91(7): 818-826, 1990
Original article
THE INFLUENCE OF REFLUX OF BILE AND PANCREATIC JUICE ON GASTRIC CARCINOGENESIS IN RATS
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1) The Department of Gastroenterological Surgery, Aichi Cancer Hospital, Nagoya, Japan Hiroshi Kojima1), Ken Kondo2), Hiroshi Takagi2) |
At the first experiment, seventy male Wistar rats were subjected to gastrojejunostomy for the diversion of duodenal contents into the resected stomach through the afferent and the efferent loops.
The incidence of adenocarcinoma in the afferent anastomosis were 0/8（0％）at the 10th week, 3/16 （18.8％）at the 20 th week and 7/20（35％）at the 40th week, so the incidence was apt to rise in parallel to the time. In the second experiment, ninty rats were divided into 4 groups：Group I received the same operation as the first experiment, group II received the operation with Braun's anastomosis, group III received the operation for reflux of bile alone to the remnant stomach, and group IV received the operation for reflux of pancreatic juice alone. Animals surviving after surgery were sacrificed at the 40th week. The incidence were 33.3％ in group I, 0％ in group II, 0％ in group III, and 8.3％ in group IV, respectively.
These findings suggest that reflux of duodenal contents（both bile and pancreatic juice）is an important factor in the gastric stump carcinogenesis.
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