J.Jpn. Surg. Soc.. 91(3): 326-334, 1990
Original article
ENHANCED EFFECT OF INTRA-ARTERIAL ADRIAMYCIN ADMINISTRATION IN COMBINATION WITH DEGRADABLE STARCH MICRO-SPHERES ON AN INTRA-ARTERIAL CHEMOTHERAPY MODEL OF NUDE RATS TRANSPLANTED OF HUMAN GASTRIC CANCER
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Department of Surgery, Research Institute for Microbial Diseases,Osaka University, Osaka, Japan Yasuo Sakamoto, Masahide Fujita, Jun Ota, Ryohei Sugiyama, Takuji Sugimoto, Tetsuo Taguchi |
An intra-arterial chemotherapy model of the nude rats transplanted of human gastric cancer xenografts (H-154) in the hind-limbs was used for this study. Drug was administered through a catheter inserted into the carotid artery with the tip in the common iliac artery.
In the pharmacological study, increase of regional uptake of ADR and decrease of systemic distribution of ADR were recognized in some degreee.
DSM 30mg/kg, which caused temporary arrest of blood flow in the tumor, had an only weak effect on tumor growth. ADR 3mg/kg mixed with DSM 30mg/kg was more effective than ADR 3mg/kg solution. Furthermore, mixture of ADR 2mg/kg and DSM 30mg/kg had a greater effect on tumor growth than ADR 2mg/kg following DSM 30mg/kg.
It seems that embolization by DSM, retention of ADR in regional tissues and cytotoxic effect of ADR have contributed to such a strong effect of ADR mixed with DSM.
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