J.Jpn. Surg. Soc.. 91(2): 163-168, 1990
Original article
EFFECTS OF THE ADMINISTRATION OF URINARY TRYPSIN INHIBITOR
ON THE MORPHOLOGY AND FUNCTION OF PLATELETS IN THE RAT SEPTIC MODELS
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The Emergency Care Unit, Kansai Medical University, Moriguchi, Japan Tomoyuki Taniguchi, Hiroyasu Ishikura, Naoshi Takeyama, Daisuke Takagi, Yasuhide Kitazawa, Takaya Tanaka |
At formation of CLP, 5,000U/kg/h of UTI was serially administered intraperitoneally and blood was sampled after 16 hours. Comparative study among sham-operation group, CLP group, and CLP+UTI group revealed : 1) inhibition of the deatelets of platelet counts and appearance of large-sized, active platelets by UTI in the CLP+UTI group, 2) increase of platelet maximum aggregation rate (MAR) by ADP and increase of collagen in the CLP group, while inhibition in the CLP+UTI group and 3) by HPLC evaluation of adenine nucleotide in the platelet, increased levels of total ATP and ADP in the CLP group, particularly, increases of ATP in the metabolic pool and ADP in the granular pool. CLP+UTI group did not show these changes in the adenylate pool. UTI was thus considered to stabilize the platelet cycle in sepsis.
Platelets under septic state might be hyperactive, and thrombosis is easy to occur. UTI administration might work for maintaining constancy of the platelet internal environment and improve septic state because adenine nucleotide level in the platelet did not change in the CLP+UTI group though changed in the CLP group.
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