J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1699KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 91(1): 123-129, 1990

Original article

IMMUNOHISTOLOGICAL STUDY ON RAS AND MYC ONCOGENE PRODUCTS IN PANCREATIC CANCER

Second Department of Surgery, Nagasaki University School of Medicine, Nagasaki, Japan
Department of Oncology, Nagasaki University School of Medicine, Nagasaki, Japan

Koichi Motoshima, Norihiro Kohara, Toshiaki Shiogama, Masaaki Fujii, Shungo Nakago, Tsukasa Tsunoda, Yasuhiko Nagata

Surgical treatment of the pancreatic cancer is currently unsatisfactory. By using anti-K, H, N-ras monoclonal and anti-myc polyclonal antibodies, paraffin-embeded tissue specimens of the carcinoma in digestive organs were immunohistologically studied. Then, the incidence of expression of these oncogenes and correlative studies of survival rate and disease stage of pancreatic cancer were analyzed.
High incidence of expression of ras oncogene in the carcinoma of the pancreas and biliary tract was obtained. Frequency of expression of ras oncogene was correlated to disease stage and T factor for staging the carcinoma of the pancreas. Prognoses of 6 cases of pancreatic cancer without expression of ras oncogene were better than that of pancreatic cancer expressed ras oncogene.

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