J.Jpn. Surg. Soc.. 90(11): 1879-1889, 1989
Original article
EFFECT OF ILEO-JEJUNAL TRANSPOSITION (IJT) ON GASTROINTESTINAL HORMONES AND INTESTINAL STRUCTURE IN DOGS
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The First Department of Surgery, Tohoku University School of Medicine, Sendai, Japan Morihiko Toda, Iwao Sasaki, Hiroo Naito, Yuji Funayama, Yoshiro Suzuki, Michinaga Takahashi, Seiki Matsuno |
IJT was performed by isoperistaltic interposition of the distal fourth of the small bowel in the jejunum 15cm distal from the ligament of Treitz. A test meal (carbohydrate-and fat-rich) loading was carried out in 5 dogs before and 4 and 12 weeks after the operatin. Plasma concentrations of gastrointestinal hormones (GLI, GI, GIP and gastrin) were measured by radioimmunoassay using the antibodies. The six mongrel dogs were used for the histological studies.
Following IJT hyperenteroglucogonemia was observed, especially in postprandial state. An increase of the mucosal thickness in the whole intestine was observed after IJT. This suggested the possibility that enteroglucagon stimulates intestinal mucosal growth as a circulating hormone.
Postprandial plasma GIP levels after IJT were significantly lower at the 90, 120 and 150 min after the test meal loading than those of the preoperative state. Plasma gastrin levels were no significant differences before and after surgery.
These observations lead us to conclude that enteroglucagon may play an important role in intestinal adaptation mechanisms after IJT.
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