J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 403KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 90(5): 681-685, 1989

Original article

DNA PLOIDY PATTERN IN DIFFUSELY INFILTRATING CARCINOMAS OF THE STOMACH

Surgery II, School of Medicine, Kanazawa University, Kanazawa, Japan

Yutaka Yonemura, Kazuo Sugiyama, Toru Kamata, Takashi Fujimura, Akio Yamaguchi, Koichi Miwa, Itsuo Miyazaki

Analysis of DNA ploidy patterns was performed on 76 diffusely infiltrating carcinomas of the stomach and the results correlated with histologic findings and outcome. Twenty six cases were diploid (34%) and 50 cases were aneuploid. There was no correlation between DNA ploidy and histologic type, depth of invasion, lymphatic invasion, evidence of peritoneal dissemination or curability. In aneuploid tumors, incidence of vascular invasin was significantly higher than that in diploid tumors (p<0.05). In addition, the patients with aneuploid tumors had a poor prognosis than those with diploid tumors. These results indicate that DNA ploidy patterns may possibly be a useful prognostic marker for diffusely infiltrating carcinomas of the stomach.

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