J.Jpn. Surg. Soc.. 90(1): 120-126, 1989
Original article
CLINICAL STUDIES ON 228 RENAL TRANSPLANTS
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Department of Organ Transplantatin, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan Hisayuki Sugimoto, Nobuo Akiyama, Osamu Otsubo*), Shinji Tomikawa, Kunji Mita, Yoshihumi Bekku, Toshikazu Imai |
Both patient survival and graft survival rates of HLA identical sibling (Id Sib), living related transplantation with ciclosporin (CYA), transplantation with donor-specific transfusion and antiIymphocyte globulin (DST･ALG) and cadaveric transplantation with circlosporin (CYA･Cad) groups were better than those of living related transplantation with ALG, without DST (ALG), living related transplantation with azathioprine and steroid (Non-DST･Non-ALG) and cadaveric transplantation without ciclosporin (Conv･Cad) groups. The incidence and severity of acute rejection were lower in Id Sib, CYA, DST･ALG and CYA･Cad groups than in other groups.
The incidence of infections was the highest in Conv･Cad group and that of fatal infections was higher in ALG, Non-DST･Non-ALG and Conv･Cad groups than in other groups. These results indicated that acute rejectin and infectin were two important factors that influenced the survival rates of these patients.
Up to now, the graft survival rate of CYA･Cad group has been much improved as compared to that of Conv･Cad group and was better than those of ALG and Non-DST･Non-ALG groups. The fact urges us to promote more cadaveric renal transplantation in our country by virtue of ciclosporin.
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