J.Jpn. Surg. Soc.. 89(12): 1990-1996, 1988
Original article
RENAL MICROCIRCULATION IN EXPERIMENTAL ACUTE PANCREATITIS OF DOGS ―THE EFFECT OF PANCREATIC PROTEASE INHIBITOR AND DOPAMINE―
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The First Department of Surgery, Osaka City University Medical School, Osaka, Japan Hideki Nishiwaki, Ichikun Koh, Gakushu Kanazawa, Akihito Hiura, Katsusuke Satake, Kaoru Umeyama |
In mongrel dogs acute pancreatitis was experimentally introduced by autologus bile added trypsin injection into the pancreatic duct. The effect of new synthesized pancreatic protease inhibitor (PATM) and dopamine in a dose of 3mg/kg/hr and 10μg/kg/min were investigated, respectively.
In acute pancreatitis dogs, renal arterial blood flow and renal tissue blood flow immediately fell and gradually decreased in time course of experiment and renal vascular resistance increased from 2 hours after onset of pancreatitis.
When pancreatic protease inhibitor (PATM) was infused in acute pancreatitis dogs, blood pressure and pulse pressure relatively preserved during the experiment. Renal blood flow and renal tissue blood flow were maintained during the first 1 hour and thereafter slightly decreased, however which was less than that of no PATM treated dogs. When dopamine was infused in acute pancreatitis dogs, blood pressure was maintained during the first 90 minutes thereafter remarkably decreased. Renal blood flow was maintained within 60 minutes, however it remarkably decreased at the end of the experiment.
This study suggested that renal microcirculation was disturbed from early period of acute pancreatitis in dogs and pancreatic protease inhibitor (PATM) had a beneficial effect of maintain the renal microcirculation.
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