J.Jpn. Surg. Soc.. 89(10): 1603-1610, 1988

---

Original article

EVALUATION OF THE WATER-ELECTROLYTE METABOLISM IN THE PATIENTS WITH UPPER GI TRACT CANCER
ーTHE DYNAMIC STATUS OF SECRETION OF α-hANP LEVELSー

For the purpose of evaluation of the water-electrolyte metabolism in upper GI tract surgery, I measured alpha-human atrial natriuretic polypeptide (α-hANP) and other parameters of twenty-eight patients daily for seven days after operation. The subjects were divided in four groups as follows ; 6 r-thoracal and abdominal esophagectomy (r-TA group) ;41-thoracoabdominal total gastrectomy (1-TA group), 8 abdominal total gastrectomy (TMR group) and 10 partial gastrectomy (PMR group).
Plasma α hANP levels in r-TA group were significantly higher than those in PMR group on the first, second, third and seventh postoperative days (p＜0.05). Furthermore, those in 1-TA group were also significantly higher compared to those in PMR group on the second and seventh postoperative days (p＜ 0.05).
Significant correlation between plasma α hANP level and water balance was detected in transabdominal groups (TMR, PMR).
However, this correlation was not found in thoracoabdominal groups (r-TA, 1-TA). There was no correlation among α hANP level, heart rate and blood pressure. Serum and urinary N a/K ratio was lower in r-TA group, 1-TA group, TMR group, and PMR group in descending order.
Consequently, plasma α hANP Ievel plays an important role in water-electrolyte metabolism during the perioperative period.
A good group of the dynamic status of the secretion of α hANP levels might be a very useful index for the evaluation of the magnitude of surgical stress.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.