J.Jpn. Surg. Soc.. 89(4): 595-601, 1988
Original article
PULMONARY FLOW-RESISTANCE RELATION IN ALLOGRAFTS TEN DAYS AFTER SINGLE LUNG TRANSPLANTATION IN DOGS
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Department of Cardiovascular Surgery, Heart Institute of Japan, Tokyo Women’s Medical College, Tokyo, Japan Kiyoyuki Eishi |
Fourteen dogs underwent single lung transplantation.All dogs received azathioprine (50mg ; given orally) and methylprednisolone sodium succinate (125mg ; given intravenously) every day after operation. Eight dogs survived up to ten days after operation. In the survived recipients and the five healthy dogs, pulmonary fiow-resistance relations were investigated. Pulmoanry fiow was exactly regulated by the pump system, which drained from both cavae and returned to right atrium via azygos vein. The pulmonary artery of native lung or right lung was clamped prior to the measurement. Pulmoanry vascular resistance was recorded with the increase of pulmoanry flow at the range from 0.3L/min. to 2.0 L/min. by 0.1L/min.. Lung water was measured by means of Wood’s method. Radiographical and patfhological examinations were appended.
The five allografts received complete studies (successful group) were twice lung water of the healthy lungs (control group) (successful group ; 95.6±16.7g, control group ; 47.8±7.5g), and chest roentgenograms of successful group showed mild or moderate consolidation. The other allo-grafts (unsuccessful group), including ones died before investigations, were four times lung water of control group (unsuccessful group ; 211.0±89.6g), and the chest roentgenograms showed severe consolidation. But any difference was not found in any pulmonary flow between the pulmonary resistance in successful group and in control group.
These results show that the allografts, which is under about twice lung water of normal lung, maintains enough pulmoanry vascular function, and I concluded that single lung transplantation can be an effective treatment for pulmoanry hypertension.
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